Título: European Journal of PainImportada do Authenticus Pesquisar Publicações da Revista

Vol. 26

Páginas: 1546-1568

ISSN: 1090-3801

Editora: Wiley-Blackwell

ISI Web of Knowledge - 2 Citações

Scopus - 2 Citações

Pubmed / Medline

CORDIS: Ciências da Saúde ; Ciências da Saúde > Neurociências > Neurobiologia ; Ciências da Saúde > Neurociências > Neurofisiologia

FOS: Ciências médicas e da saúde > Medicina básica

ID Authenticus: P-00W-MTB

DOI: 10.1002/ejp.1982

Abstract (EN): Background Prelimbic medial prefrontal cortex (PL-mPFC) and nucleus accumbens core region (NAcc) play an important role in supporting several executive cognitive mechanisms, such as spatial working memory (WM). Recently, this circuit has been also associated with both sensory and affective components of pain. However, it is still unclear whether this circuit is endogenously engaged in neuropathic pain-related cognitive dysfunctions. Methods To answer this question, we induced the expression of halorhodopsin in local PL-mPFC neurons projecting to NAcc, and then selectively inhibited the terminals of these neurons in the NAcc while recording neural activity during the performance of a delayed non-match to sample (DNMS) spatial WM task. Within-subject behavioural performance and PL-mPFC to NAcc circuit neural activity was assessed after the onset of a persistent rodent neuropathic pain model-spared nerve injury (SNI). Results Our results revealed that the induction of the neuropathy reduced WM performance, and altered the interplay between PL-mPFC and NAcc neurons namely in increasing the functional connectivity from NAcc to PL-mPFC, particularly in the theta-band spontaneous oscillations; in addition, these behavioural and functional perturbations were partially reversed by selective optogenetic inhibition of PL-mPFC neuron terminals into the NAcc during the DNMS task delay-period, without significant antinociceptive effects. Conclusions Altogether, these results strongly suggest that the PL-mPFC excitatory output into the NAcc plays an important role in the deregulation of WM under pain conditions. Significance Selective optogenetic inhibition of prefrontal-striatal microcircuit reverses pain-related working memory deficits but has no significant impact on pain responses. Neuropathic pain underlies an increase of functional connectivity between the nucleus accumbens core area and the prelimbic medial prefrontal cortex mediated by theta-band activity.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 23