Título: Physical Chemistry Chemical PhysicsImportada do Authenticus Pesquisar Publicações da Revista

Vol. 15 Nº 28

Páginas: 11893-11899

ISSN: 1463-9076

Editora: Royal Society of Chemistry

ISI Web of Knowledge - 9 Citações

ISI Web of Science

Scopus - 12 Citações

INSPEC

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Tecnológicas ; Ciências da Saúde

ID Authenticus: P-006-G6J

DOI: 10.1039/c3cp51215k

Abstract (EN): Graft copolymers of chitosan and maltodextrin were synthesized by reductive amination of a low molecular weight chitosan. The degree of substitution is 70% or above, as quantified by nuclear magnetic resonance spectroscopy, at molar ratios of chitosan glucosamine units and maltodextrin of 1 : 1 and 1 : 5. The high substitution degree generates a water-soluble compound at pH 7.4 by reducing the amino groups of chitosan. In addition, the copolymer self-assembles into spherical nanoparticles with diameters of about 300 nm. The mass polymer/DNA ratios at the isoelectric point are within the range of 3-3.5 for chitosan-maltodextrin nanoparticles as determined by electrophoretic mobility measurements. These results confirm that DNA interacts efficiently with the copolymer nanoparticles indicating a potential application of the system for DNA delivery.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7